Alzheimer's disease biomarkers and their current use in clinical research and practice

TR Hunter, LE Santos, F Tovar-Moll… - Molecular Psychiatry, 2024 - nature.com
While blood-based tests are readily available for various conditions, including
cardiovascular diseases, type 2 diabetes, and common cancers, Alzheimer's disease (AD) …

Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset

Y Li, D Yen, RD Hendrix, BA Gordon… - Annals of …, 2024 - Wiley Online Library
Objective A clock relating amyloid positron emission tomography (PET) to time was used to
estimate the timing of biomarker changes in sporadic Alzheimer disease (AD). Methods …

[HTML][HTML] Alcohol Use Disorder and Dementia: A Review

NM Zahr - Alcohol Research: Current Reviews, 2024 - ncbi.nlm.nih.gov
PURPOSE By 2040, 21.6% of Americans will be over age 65, and the population of those
older than age 85 is estimated to reach 14.4 million. Although not causative, older age is a …

Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals

C Xiong, J Luo, DA Wolk, LM Shaw… - Nature …, 2024 - nature.com
Blood-based biomarkers of Alzheimer disease (AD) may facilitate testing of historically
under-represented groups. The Study of Race to Understand Alzheimer Biomarkers …

Head‐to‐head comparison of leading blood tests for Alzheimer's disease pathology

SE Schindler, KK Petersen, B Saef… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Blood tests have the potential to improve the accuracy of Alzheimer's
disease (AD) clinical diagnosis, which will enable greater access to AD‐specific treatments …

Benchmarking of a multi‐biomarker low‐volume panel for Alzheimer's disease and related dementia research

L Ibanez, M Liu, A Beric, J Timsina… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION In the research setting, obtaining accurate established biomarker
measurements and maximizing use of the precious samples is key. Accurate technologies …

Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer's disease

KL Meeker, PH Luckett, NR Barthélemy… - Brain …, 2024 - academic.oup.com
Alzheimer's disease biomarkers are crucial to understanding disease pathophysiology,
aiding accurate diagnosis and identifying target treatments. Although the number of …

Plasma amyloid beta X‐42/X‐40 ratio and cognitive decline in suspected early and preclinical Alzheimer's disease

J Vogelgsang, N Hansen, M Stark… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Blood‐based biomarkers are a cost‐effective and minimally invasive
method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study …

Amyloid-beta metabolism in age-related neurocardiovascular diseases

E Aivalioti, G Georgiopoulos, S Tual-Chalot… - European Heart …, 2025 - academic.oup.com
Epidemiological evidence suggests the presence of common risk factors for the
development and prognosis of both cardio-and cerebrovascular diseases, including stroke …

Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer's disease

V Devanarayan, T Doherty, A Charil… - Alzheimer's & …, 2024 - Wiley Online Library
BACKGROUND This study investigated the potential of phosphorylated plasma Tau217 ratio
(pTau217R) and plasma amyloid beta (Aβ) 42/Aβ40 in predicting brain amyloid levels …