Dietary flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns

J Khan, PK Deb, S Priya, KD Medina, R Devi… - Molecules, 2021 - mdpi.com
Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …

Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFκB) signaling in cardiovascular diseases: a mini review

KW Choy, D Murugan, XF Leong, R Abas… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and
heart failure are the leading causes of morbidity and mortality worldwide. One of the major …

The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics

Y Zhou, M Li, J Song, Y Shi, X Qin, Z Gao, Y Lv, G Du - Scientific reports, 2020 - nature.com
Puerarin has shown unique pharmacological effects on myocardial ischemia (MI). Changing
the crystal form is an effective approach to improve the cardioprotective effects of puerarin …

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

D Kothari, WD Lee, SK Kim - Antioxidants, 2020 - mdpi.com
Allium species are revered worldwide as vegetables, condiments, and spices as well as the
therapeutic agents in traditional medicine. The bioactive compounds in alliums mainly …

Catecholamine-induced cardiotoxicity: a critical element in the pathophysiology of stroke-induced heart injury

Y Du, LJ Demillard, J Ren - Life Sciences, 2021 - Elsevier
Cerebrovascular diseases such as ischemic stroke, brain hemorrhage, and subarachnoid
hemorrhage provoke cardiac complications such as heart failure, neurogenic stress-related …

NF-κB, A potential therapeutic target in cardiovascular diseases

W Cheng, C Cui, G Liu, C Ye, F Shao… - … Drugs and Therapy, 2023 - Springer
Cardiovascular diseases (CVDs) are the leading cause of death globally. Atherosclerosis is
the basis of major CVDs–myocardial ischemia, heart failure, and stroke. Among numerous …

Harnessing the therapeutic potential of fisetin and its nanoparticles: Journey so far and road ahead

S Vishwas, SK Singh, M Gulati, A Awasthi… - Chemico-Biological …, 2022 - Elsevier
Fisetin (FS) is a bioactive flavonoid obtained mostly from apple and strawberry and
classified under the category of food supplements due to numerous pharmacological effects …

Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock

IMN Molagoda, JACC Jayasingha, YH Choi… - Scientific Reports, 2021 - nature.com
Fisetin is a naturally occurring flavonoid that possesses several pharmacological benefits
including anti-inflammatory activity. However, its precise anti-inflammatory mechanism is not …

[HTML][HTML] Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure

Z Zhang, Z Yang, S Wang, X Wang, J Mao - Biomedicine & …, 2024 - Elsevier
The pyroptosis of cardiomyocytes has become an essential topic in heart failure research.
The abnormal accumulation of these biological factors, including angiotensin II, advanced …

Roles of flavonoids in ischemic heart disease: Cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury

H Xu, S Yu, C Lin, D Dong, J Xiao, Y Ye, M Wang - Phytomedicine, 2024 - Elsevier
Background Flavonoids are extensively present in fruits, vegetables, grains, and medicinal
plants. Myocardial ischemia and reperfusion (MI/R) comprise a sequence of detrimental …