[HTML][HTML] Epidemiology of bladder cancer in 2023: a systematic review of risk factors
Context Bladder cancer (BC) is common worldwide and poses a significant public health
challenge. External risk factors and the wider exposome (totality of exposure from external …
challenge. External risk factors and the wider exposome (totality of exposure from external …
An overview of cancer health disparities: new approaches and insights and why they matter
TZ Minas, M Kiely, A Ajao, S Ambs - Carcinogenesis, 2021 - academic.oup.com
Cancer health disparities remain stubbornly entrenched in the US health care system. The
Affordable Care Act was legislation to target these disparities in health outcomes. Expanded …
Affordable Care Act was legislation to target these disparities in health outcomes. Expanded …
The impact of site-specific digital histology signatures on deep learning model accuracy and bias
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …
Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors
The immune checkpoint inhibitor (ICI) pembrolizumab is US FDA approved for treatment of
solid tumors with high tumor mutational burden (TMB-high;≥ 10 variants/Mb). However, the …
solid tumors with high tumor mutational burden (TMB-high;≥ 10 variants/Mb). However, the …
Genomic context of NTRK1/2/3 fusion-positive tumours from a large real-world population
CB Westphalen, MG Krebs, C Le Tourneau… - NPJ precision …, 2021 - nature.com
Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers
in solid tumours. This study aimed to interrogate a large real-world database of …
in solid tumours. This study aimed to interrogate a large real-world database of …
LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway
Y He, X Jiang, L Duan, Q Xiong, Y Yuan, P Liu, L Jiang… - Molecular cancer, 2021 - Springer
Background Non-small cell lung cancer (NSCLC) is the most common type of human lung
cancers, which has diverse pathological features. Although many signaling pathways and …
cancers, which has diverse pathological features. Although many signaling pathways and …
DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …
Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations
J Carrot-Zhang, G Soca-Chafre, N Patterson… - Cancer discovery, 2021 - AACR
Inherited lung cancer risk, particularly in nonsmokers, is poorly understood. Genomic and
ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations …
ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations …
Germline genetic contribution to the immune landscape of cancer
Understanding the contribution of the host's genetic background to cancer immunity may
lead to improved stratification for immunotherapy and to the identification of novel …
lead to improved stratification for immunotherapy and to the identification of novel …
Genetic ancestry correlates with somatic differences in a real-world clinical cancer sequencing cohort
Accurate ancestry inference is critical for identifying genetic contributors of cancer disparities
among populations. Although methods to infer genetic ancestry have historically relied upon …
among populations. Although methods to infer genetic ancestry have historically relied upon …