It is widely appreciated that larvae of the nematode Caenorhabditis elegans arrest
development by forming dauer larvae in response to multiple unfavorable environmental …

The intestine is one of the major organs in C. elegans and is largely responsible for food
digestion and assimilation as well as the synthesis and storage of macromolecules. In …

Development is typically studied as a continuous process under laboratory conditions, but
wild animals often develop in variable and stressful environments. C. elegans larvae hatch …

Cell-division control affects many aspects of development. Caenorhabditis elegans cell-
cycle genes have been identified over the past decade, including at least two distinct Cyclin …

The molecular pathways that link nutritional cues to developmental programs are poorly
understood. Caenorhabditis elegans hatchlings arrest in a dormant state termed" L1 …

The transition from proliferating precursor cells to post-mitotic differentiated cells is crucial for
development, tissue homeostasis, and tumor suppression. To study cell-cycle exit during …

The extracellular matrix (ECM) is a network of structural proteins, glycoproteins and
proteoglycans that assists independent cells in aggregating and forming highly organized …

The core machinery that drives the eukaryotic cell cycle has been thoroughly investigated
over the course of the past three decades. It is only more recently, however, that light has …

During animal development, a single fertilized egg forms a complete organism with tens to
trillions of cells that encompass a large variety of cell types. Cell cycle regulation is therefore …

Although now dogma, the idea that nonvertebrate organisms such as yeast, worms, and flies
could inform, and in some cases even revolutionize, our understanding of oncogenesis in …