[HTML][HTML] Glycosylation sterically inhibits platelet adhesion to von Willebrand factor without altering intrinsic conformational dynamics
Background A molecular basis for von Willebrand factor (VWF) self‐inhibition has been
proposed by which the N‐terminal and C‐terminal flanking sequences of the globular A1 …
proposed by which the N‐terminal and C‐terminal flanking sequences of the globular A1 …
Enhanced local disorder in a clinically elusive von willebrand factor provokes high-affinity platelet clumping
Mutation of the cysteines forming the disulfide loop of the platelet GPIbα adhesive A1
domain of von Willebrand factor (VWF) causes quantitative VWF deficiencies in the blood …
domain of von Willebrand factor (VWF) causes quantitative VWF deficiencies in the blood …
Prediction of binding characteristics between von Willebrand factor and platelet glycoprotein Ibα with various mutations by molecular dynamic simulation
S Goto, H Oka, K Ayabe, H Yabushita, M Nakayama… - Thrombosis …, 2019 - Elsevier
Introduction Binding of platelet glycoprotein (GP) Ibα with von-Willebrand factor (VWF)
exclusively mediates the initial platelet adhesion to injured vessel wall. To understand the …
exclusively mediates the initial platelet adhesion to injured vessel wall. To understand the …
Evidence for the misfolding of the a1 domain within multimeric von Willebrand factor in type 2 von Willebrand disease
Von Willebrand factor (VWF), an exceptionally large multimeric plasma glycoprotein,
functions to initiate coagulation by agglutinating platelets in the blood stream to sites of …
functions to initiate coagulation by agglutinating platelets in the blood stream to sites of …
A p. Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD
L Bury, E Falcinelli, H Kuchi Bhotla… - Blood …, 2022 - ashpublications.org
Abstract Gain-of-function (GOF) variants in GP1BA cause platelet-type von Willebrand
disease (PT-VWD), a rare inherited autosomal dominant bleeding disorder characterized by …
disease (PT-VWD), a rare inherited autosomal dominant bleeding disorder characterized by …
The von willebrand factor a1–collagen III interaction is independent of conformation and type 2 von willebrand disease phenotype
The blood von Willebrand factor (VWF) mediates platelet adhesion to injured vessels by
sequestering platelets from blood flow and depositing them to collagen and other exposed …
sequestering platelets from blood flow and depositing them to collagen and other exposed …
[HTML][HTML] Platelet‐type von Willebrand disease: Local disorder of the platelet GPIbα β‐switch drives high‐affinity binding to von Willebrand factor
Background Mutations in the β‐switch of GPIbα cause gain‐of‐function in the platelet‐type
von Willebrand disease. Structures of free and A1‐bound GPIbα suggest that the β‐switch …
von Willebrand disease. Structures of free and A1‐bound GPIbα suggest that the β‐switch …
Análisis genético y epigenético de enfermedades heredadas o influenciadas por el ambiente: dos ejemplos
DC Polanía Villanueva - 2018 - repositorio.uniandes.edu.co
La presente tesis doctoral propone dos ejemplos para estudiar enfermedades heredadas o
influenciadas por el ambiente. Desde una perspectiva epigenética, se estudió la metilación …
influenciadas por el ambiente. Desde una perspectiva epigenética, se estudió la metilación …