Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

Carboxy-terminus of Hsc70-interacting protein (CHIP) functions both as a molecular co-
chaperone and ubiquitin E3 ligase playing a critical role in modulating the degradation of …

Tauopathies are neurodegenerative diseases that involve the pathological accumulation of
tau proteins; in this family are Alzheimer disease, corticobasal degeneration, and chronic …

Accumulating evidences have suggested that extracellular vesicles (EVs) are crucial players
in the pathogenesis of ischemic brain injury. This study was designed to explore the specific …

The ubiquitin‐proteasome pathway and autophagy‐lysosome pathway are two major routes
for clearance of aberrant cellular components to maintain protein homeostasis and normal …

Introduction Cerebral edema is a key contributor to death and disability in several forms of
brain injury. Current treatment options are limited, reactive, and associated with significant …

The invention provides compositions and methods for the preparation, manufacture and
therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral …

Endoplasmic reticulum (ER) stress-induced apoptosis and autophagy flux blockade
significantly contribute to neuronal pathology of spinal cord injury (SCI). Yet, the molecular …

Ischemic stroke (IS) is a leading cause of morbidity and mortality globally and triggers a
series of reactions leading to primary and secondary brain injuries and permanent …

Parvoviridae family viruses are small non-enveloped icosahedral capsid viruses
characterized by a single stranded DNA genome. Parvoviridae family viruses consist of two …