Dendritic cell (DC) vaccines induce specific immune responses that can selectively
eliminate target cells. In recent years, many studies have been conducted to explore DC …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme with
immune-regulating activities in many contexts, such as fetal protection, allograft protection …

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and
cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of …

Abstract Treatment of cancers has always been a challenge for physicians. Typically,
several groups of anti-cancer medications are needed for effective management of an …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

Despite recent advancements in the treatment of hematologic malignancies and the
emergence of newer and more sophisticated therapeutic approaches such as …

The microenviroment of acute myelogenous leukemia (AML) is suppressive for immune
effector cells. Regulatory T cells (Tregs) have been recognized as a contributor factor and …

Although the earliest—rudimentary—attempts at exploiting the immune system for cancer
therapy can be traced back to the late 18th Century, it was not until the past decade that …

Regulatory T cells (Tregs) could maintain the characteristics of stem cells and inhibit the
differentiation of normal hematopoietic stem/progenitor cells. Recent studies have shown …

Microenvironmental factors contribute to the immune dysfunction characterizing acute
myeloid leukemia (AML). Indoleamine 2, 3-dioxygenase 1 (IDO1) is an interferon (IFN)-γ …