Salamanders and frogs are distinct orders of Amphibians with very different immune systems
during adult life, exhibiting varying potential for scar free repair and regeneration. While …

This review explores the historical and current state of our knowledge about urodele limb
regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of …

The failure to replace damaged body parts in adult mammals results from a muted growth
response and fibrotic scarring. Although infiltrating immune cells play a major role in …

Animals capable of regenerating multiple tissue types, organs, and appendages after injury
are common yet sporadic and include some sponge, hydra, planarian, and salamander (ie …

Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

The salamander has the remarkable ability to regenerate its limb after amputation. Cells at
the site of amputation form a blastema and then proliferate and differentiate to regrow the …

Understanding how the limb blastema is established after the initial wound healing
response is an important aspect of regeneration research. Here we performed parallel …

Abstract Recent studies in Drosophila, Hydra, planarians, zebrafish, mice, indicate that cell
death can open paths to regeneration in adult animals. Indeed injury can induce cell death …

The experimental study of amphibian limb regeneration spans most of the 20th century and
the first decade of the 21st century. We first review the major questions investigated over this …

The ability to regenerate amputated or injured tissues and organs is a fascinating property
shared by several invertebrates and, interestingly, some vertebrates. The mechanism of …