By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

To comprehensively understand tissue and organism physiology and pathophysiology, it is
essential to create complete three-dimensional (3D) cellular maps. These maps require …

One intrinsic yet critical issue that troubles the field of fluorescence microscopy ever since its
introduction is the unmatched resolution in the lateral and axial directions (ie, resolution …

High-speed visualization of three-dimensional (3D) processes across a large field of view
with cellular resolution is essential for understanding living systems. Light-field microscopy …

Holistic understanding of physio-pathological processes requires noninvasive 3D imaging in
deep tissue across multiple spatial and temporal scales to link diverse transient subcellular …

Multiplexed imaging enables measurement of multiple proteins in situ, offering an
unprecedented opportunity to chart various cell types and states in tissues. However, cell …

With the emergence of powerful deep learning tools, more and more effective deep
denoisers have advanced the field of image denoising. However, the huge progress made …

Carbon dots (CDs) are a new type of fluorescent carbon nanomaterials with highly
carbonized cores and surface groups. The outstanding properties of CDs, such as excellent …

Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal
information in imaging data), a self-supervised learning method for removing Poisson …

Widefield microscopy is widely used for non-invasive imaging of biological structures at
subcellular resolution. When applied to a complex specimen, its image quality is degraded …