The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

Advances in molecular biology, microfluidics and bioinformatics have empowered the study
of thousands or even millions of individual cells from malignant tumours at the single-cell …

Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

Single-cell omics aim at charting the different types and properties of all cells in the human
body in health and disease. Over the past years, myriads of cellular phenotypes have been …

Multiplex imaging technologies are increasingly used for single-cell phenotyping and spatial
characterization of tissues; however, transparent methods are needed for comparing the …

Objectives Aging is associated with altered immune function and chronic low‐grade
inflammation, referred to as immunosenescence. As breast cancer is an age‐related …

Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin
lymphoma with an aggressive clinical course. To investigate the potential of immune …

In melanoma, the lymphocytic infiltrate is a prognostic parameter classified morphologically
into 'brisk','non-brisk'and 'absent'entailing a functional association that has never been …

Recent single-cell technologies have enabled researchers to simultaneously assess the
transcriptomes and other modalities of thousands of cells within their spatial context. Here …

For decades, pathologists have visually inspected tissue slides stained by H&E and simple,
one marker at a time immunohistochemistry (IHC). Novel technologies are now allowing …