Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified.
Although 6q losses are commonly present, recurring gene losses in this region remain to be …

Protein-RNA interactions are fundamental to core biological processes, such as mRNA
splicing, localization, degradation, and translation. We developed a photoreactive …

Personalized medicine is focused on research disciplines which contribute to the
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …

Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack of
synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the …

Parkinson's disease (PD) is a progressive, primarily motor disorder that is characterized by
loss of dopaminergic (DA) neurons within the substantia nigra (SN). Cell death in PD has …

The transcription factor NF-κB (nuclear factor κB) serves to up-regulate gene expression in
response to precarious signals such as the pro-inflammatory cytokines TNF (tumour …

The RTS, S candidate malaria vaccine can protect against controlled human malaria
infection (CHMI), but how protection is achieved remains unclear. Here, we have analyzed …

Abstract The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-
terminal transcriptional activation domain, required for its cellular function. In the present …

Abstract Exportin 1 (XPO1) mediates nuclear export of many cellular factors known to play
critical roles in malignant processes, and selinexor (KPT-330) is the first XPO1-selective …