Targeting macrophages in cancer immunotherapy

Z Duan, Y Luo - Signal transduction and targeted therapy, 2021 - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

The multifunctional role of herbal products in the management of diabetes and obesity: a comprehensive review

MM Rahman, MR Islam, S Shohag, ME Hossain… - Molecules, 2022 - mdpi.com
Obesity and diabetes are the most demanding health problems today, and their prevalence,
as well as comorbidities, is on the rise all over the world. As time goes on, both are …

Evaluating the polarization of tumor-associated macrophages into M1 and M2 phenotypes in human cancer tissue: technicalities and challenges in routine clinical …

SD Jayasingam, M Citartan, TH Thang… - Frontiers in …, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment
have gained much interests as basic science regarding their roles in tumor progression …

Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance

T Pereira-Veiga, S Schneegans, K Pantel, H Wikman - Cell Reports, 2022 - cell.com
Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Implications of macrophage polarization in autoimmunity

SC Funes, M Rios, J Escobar‐Vera, AM Kalergis - Immunology, 2018 - Wiley Online Library
Macrophages are extremely heterogeneous and plastic cells with an important role not only
in physiological conditions, but also during inflammation (both for initiation and resolution) …

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

MA Cannarile, M Weisser, W Jacob, AM Jegg… - … for immunotherapy of …, 2017 - Springer
The tumor-permissive and immunosuppressive characteristics of tumor-associated
macrophages (TAM) have fueled interest in therapeutically targeting these cells. In this …

Estrogen receptor signaling in the immune system

B Chakraborty, J Byemerwa, T Krebs, F Lim… - Endocrine …, 2023 - academic.oup.com
The immune system functions in a sexually dimorphic manner, with females exhibiting more
robust immune responses than males. However, how female sex hormones affect immune …

Challenges and new technologies in adoptive cell therapy

P Zhang, G Zhang, X Wan - Journal of Hematology & Oncology, 2023 - Springer
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

Regulation of iNOS on immune cells and its role in diseases

Q Xue, Y Yan, R Zhang, H Xiong - International journal of molecular …, 2018 - mdpi.com
In recent years, there have been many studies on the function of nitric oxide synthase (NOS)
in experimental animals and humans. This review analyzes and explores the relationship …