Opportunities and challenges in the diagnostic utility of dermal interstitial fluid

M Friedel, IAP Thompson, G Kasting, R Polsky… - Nature Biomedical …, 2023 - nature.com
The volume of interstitial fluid (ISF) in the human body is three times that of blood. Yet,
collecting diagnostically useful ISF is more challenging than collecting blood because the …

Microfluidic solutions for biofluids handling in on-skin wearable systems

N Kashaninejad, NT Nguyen - Lab on a Chip, 2023 - pubs.rsc.org
On-skin wearable systems for biofluid sampling and biomarker sensing can revolutionize the
current practices in healthcare monitoring and personalized medicine. However, there is still …

Encoded structural color microneedle patches for multiple screening of wound small molecules

M Lu, X Zhang, D Xu, N Li, Y Zhao - Advanced Materials, 2023 - Wiley Online Library
Detection of biomarkers associated with wound conditions provides in‐depth healthcare
information and benefits wound healing treatment. The current aim of wound detection is to …

A conductive hydrogel microneedle‐based assay integrating PEDOT: PSS and Ag‐Pt nanoparticles for real‐time, enzyme‐less, and electrochemical sensing of …

P GhavamiNejad, A GhavamiNejad… - Advanced …, 2023 - Wiley Online Library
Continuous glucose meters (CGMs) have tremendously boosted diabetes care by
emancipating millions of diabetic patients' need for repeated self‐testing by pricking their …

A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue

L Zheng, D Zhu, W Wang, J Liu, STG Thng… - Sensors and Actuators B …, 2022 - Elsevier
Glucose is critical to all organisms. Herein, we developed a wire electrode embedded
microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid …

Cleanroom‐Free Fabrication of Microneedles for Multimodal Drug Delivery

D Ghanbariamin, M Samandari, P Ghelich… - Small, 2023 - Wiley Online Library
Microneedles have recently emerged as a powerful tool for minimally invasive drug delivery
and body fluid sampling. To date, high‐resolution fabrication of microneedle arrays (MNAs) …

Wearable Sensor Patch with Hydrogel Microneedles for In Situ Analysis of Interstitial Fluid

Y Dai, J Nolan, E Madsen, M Fratus, J Lee… - … Applied Materials & …, 2023 - ACS Publications
Continuous real-time monitoring of biomarkers in interstitial fluid is essential for tracking
metabolic changes and facilitating the early detection and management of chronic diseases …

Hydrogel microneedle-assisted assay integrating aptamer probes and fluorescence detection for reagentless biomarker quantification

H Zheng, A GhavamiNejad, P GhavamiNejad… - ACS …, 2022 - ACS Publications
Analyzing interstitial fluid (ISF) via microneedle (MN) devices enables patient health
monitoring in a minimally invasive manner and in point-of-care settings. However, most MN …

Technological Advances of Wearable Device for Continuous Monitoring of In Vivo Glucose

X Huang, C Yao, S Huang, S Zheng, Z Liu, J Liu… - ACS …, 2024 - ACS Publications
Managing diabetes is a chronic challenge today, requiring monitoring and timely insulin
injections to maintain stable blood glucose levels. Traditional clinical testing relies on …

3D printed hydrogel microneedle arrays for interstitial fluid biomarker extraction and colorimetric detection

M Razzaghi, A Seyfoori, E Pagan, E Askari… - Polymers, 2023 - mdpi.com
To treat and manage chronic diseases, it is necessary to continuously monitor relevant
biomarkers and modify treatment as the disease state changes. Compared to other bodily …