PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications

H Zhu, M Wei, J Xu, J Hua, C Liang, Q Meng, Y Zhang… - Molecular cancer, 2020 - Springer
Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies
offer only limited effectiveness. Mutation gene sequencing has shown several gene …

[HTML][HTML] Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

P Kreuzaler, Y Panina, J Segal, M Yuneva - Molecular metabolism, 2020 - Elsevier
Background It has been known for close to a century that, on average, tumors have a
metabolism that is different from those found in healthy tissues. Typically, tumors show a …

Development of synthetic lethality in cancer: molecular and cellular classification

S Li, W Topatana, S Juengpanich, J Cao, J Hu… - … and Targeted Therapy, 2020 - nature.com
Recently, genetically targeted cancer therapies have been a topic of great interest. Synthetic
lethality provides a new approach for the treatment of mutated genes that were previously …

Oncogene-driven metabolic alterations in cancer

HY Min, HY Lee - Biomolecules & therapeutics, 2017 - pmc.ncbi.nlm.nih.gov
Cancer is the leading cause of human deaths worldwide. Understanding the biology
underlying the evolution of cancer is important for reducing the economic and social burden …

Computational methods, databases and tools for synthetic lethality prediction

J Wang, Q Zhang, J Han, Y Zhao, C Zhao… - Briefings in …, 2022 - academic.oup.com
Synthetic lethality (SL) occurs between two genes when the inactivation of either gene alone
has no effect on cell survival but the inactivation of both genes results in cell death. SL …

Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data

S Sinha, D Thomas, S Chan, Y Gao, D Brunen… - Nature …, 2017 - nature.com
Two genes are synthetically lethal (SL) when defects in both are lethal to a cell but a single
defect is non-lethal. SL partners of cancer mutations are of great interest as pharmacological …

Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer

S Duffy, HK Fam, YK Wang, EB Styles… - Proceedings of the …, 2016 - National Acad Sciences
Somatic copy number amplification and gene overexpression are common features of many
cancers. To determine the role of gene overexpression on chromosome instability (CIN), we …

[HTML][HTML] Metabolic synthetic lethality in cancer therapy

V Zecchini, C Frezza - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2017 - Elsevier
Our understanding of cancer has recently seen a major paradigm shift resulting in it being
viewed as a metabolic disorder, and altered cellular metabolism being recognised as a …

[HTML][HTML] Beyond synthetic lethality: charting the landscape of pairwise gene expression states associated with survival in cancer

A Magen, AD Sahu, JS Lee, M Sharmin, A Lugo… - Cell reports, 2019 - cell.com
The phenotypic effect of perturbing a gene's activity depends on the activity level of other
genes, reflecting the notion that phenotypes are emergent properties of a network of …

Seeing the wood for the trees: a forest of methods for optimization and omic-network integration in metabolic modelling

S Vijayakumar, M Conway, P Lió… - Briefings in …, 2018 - academic.oup.com
Metabolic modelling has entered a mature phase with dozens of methods and software
implementations available to the practitioner and the theoretician. It is not easy for a …