Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance
Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
The untapped potential of ascites in ovarian cancer research and treatment
The build-up of fluid in the peritoneal cavity—ascites—is a hallmark of ovarian cancer, the
most lethal of all gynaecological malignancies. This remarkable fluid, which contains a …
most lethal of all gynaecological malignancies. This remarkable fluid, which contains a …
[HTML][HTML] Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment
E Schoutrop, L Moyano-Galceran, S Lheureux… - Seminars in cancer …, 2022 - Elsevier
Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …
Hybrid epithelial/mesenchymal phenotype (s): The 'fittest'for metastasis?
Metastasis is the leading cause of mortality among cancer patients. Dissemination enabled
by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been …
by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been …
[HTML][HTML] Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology
High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …
menopausal women as it has an insidious progression and is the deadliest gynaecological …
Orchestration of collective migration and metastasis by tumor cell clusters
A Yamamoto, AE Doak… - Annual Review of …, 2023 - annualreviews.org
Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence
supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells …
supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells …
A novel tumor-immune microenvironment (TIME)-on-Chip mimics three dimensional neutrophil-tumor dynamics and neutrophil extracellular traps (NETs)-mediated …
V Surendran, D Rutledge, R Colmon… - …, 2021 - iopscience.iop.org
Neutrophils are the most abundant type of leukocytes in the blood, traditionally regarded as
the first immune responders to infections and inflammations. In the context of tumors …
the first immune responders to infections and inflammations. In the context of tumors …
Tumor microenvironment in ovarian cancer peritoneal metastasis
S Mei, X Chen, K Wang, Y Chen - Cancer cell international, 2023 - Springer
Ovarian cancer (OC) is one of the most common gynecological malignancies with high
morbidity and mortality. The peritoneum is one of the most common metastatic sites in …
morbidity and mortality. The peritoneum is one of the most common metastatic sites in …
Resveratrol contrasts LPA-induced ovarian cancer cell migration and platinum resistance by rescuing hedgehog-mediated autophagy
A Ferraresi, A Esposito, C Girone, L Vallino, A Salwa… - Cells, 2021 - mdpi.com
Background: Ovarian cancer progression and invasiveness are promoted by a range of
soluble factors released by cancer cells and stromal cells within the tumor …
soluble factors released by cancer cells and stromal cells within the tumor …