Hepatic insulin receptor: new views on the mechanisms of liver disease

WH Lee, SM Najjar, CR Kahn, TD Hinds Jr - Metabolism, 2023 - Elsevier
Over 65% of people with obesity display the metabolic-associated fatty liver disease
(MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The …

[PDF][PDF] Metabolic syndrome and its association with nonalcoholic steatohepatitis

F Bril, A Sanyal, K Cusi - Clinics in Liver Disease, 2023 - Elsevier
There is substantial debate about the intrinsic relationship between insulin resistance, the
metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD). While NAFLD has …

Time to transition from a negative nomenclature describing what NAFLD is not, to a novel, pathophysiology-based, umbrella classification of fatty liver disease (FLD)

L Valenzuela-Vallejo, CS Mantzoros - Metabolism, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a definition of a prevalent condition that has
been given a name describing what the disease is not, mainly due to gaps in the …

Molecular mechanisms for the vicious cycle between insulin resistance and the inflammatory response in obesity

D Szukiewicz - International Journal of Molecular Sciences, 2023 - mdpi.com
The comprehensive anabolic effects of insulin throughout the body, in addition to the control
of glycemia, include ensuring lipid homeostasis and anti-inflammatory modulation …

Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study

L Valenzuela-Vallejo, P Chrysafi, M Kouvari… - Metabolism, 2023 - Elsevier
Background The role of metabolic/inflammatory hormonal systems in metabolic dysfunction
associated steatotic liver disease (MASLD) remains to be fully elucidated. Purpose To report …

[HTML][HTML] Insulin resistance and insulin sensitizing agents

L Mastrototaro, M Roden - Metabolism, 2021 - Elsevier
Insulin resistance is a common feature of obesity and type 2 diabetes, but novel approaches
of diabetes subtyping (clustering) revealed variable degrees of insulin resistance in people …

Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate

J Su, L Tang, Y Luo, J Xu, S Ouyang - Biochemical Pharmacology, 2023 - Elsevier
The number of people with diabetes worldwide is increasing annually, resulting in a serious
economic burden. Insulin resistance is a major pathology in the early onset of diabetes …

Relative Energy Deficiency in sport (REDs): endocrine manifestations, pathophysiology and treatments

AM Angelidi, K Stefanakis, SH Chou… - Endocrine …, 2024 - academic.oup.com
Research on lean, energy-deficient athletic and military cohorts has broadened the concept
of the Female Athlete Triad into the Relative Energy Deficiency in Sport (REDs) syndrome …

The Genetics of Diabetes: What We Can Learn from Drosophila

F Liguori, E Mascolo, F Vernì - International Journal of Molecular Sciences, 2021 - mdpi.com
Diabetes mellitus is a heterogeneous disease characterized by hyperglycemia due to
impaired insulin secretion and/or action. All diabetes types have a strong genetic …

Lipoatrophic diabetes in familial partial lipodystrophy type 2: From insulin resistance to diabetes

G Treiber, A Guilleux, K Huynh, O Bonfanti… - Diabetes & …, 2023 - Elsevier
ABSTRACT Aim Subjects with Familial Partial Lipodystrophy type 2 (FPLD2) are at high risk
to develop diabetes. To better understand the natural history and variability of this disease …