Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

The XRN family of 5′→ 3′ exoribonucleases is critical for ensuring the fidelity of cellular
RNA turnover in eukaryotes. Highly conserved across species, the family is typically …

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

The carboxy-terminal domain (CTD) of the RNA polymerase II (RNApII) largest subunit
consists of multiple heptapeptide repeats with the consensus sequence YSPTSPS. Different …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Small interfering RNAs and microRNAs are generated from double-stranded RNA
precursors by the Dicer endonucleases, and function with Argonaute-family proteins to …