Recent developments in cardiac simulation have rendered the heart the most highly
integrated example of a virtual organ. We are on the brink of a revolution in cardiac …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Sudden cardiac death is a major cause of death in the industrialized world, claiming
approximately 300 000 victims annually in the United States alone. In most cases, sudden …

The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …

In this paper we briefly review currently published models for human ventricular cells and
tissues. We discuss the Priebe–Beuckelmann (PB) model and the reduced version of this …

In the whole heart, millions of cardiac cells are involved in ventricular fibrillation (VF).
Experimental studies indicate that VF is sustained by re-entrant activity, and that each re …

Background—Anisotropic reentrant excitation occurs in the remodeled substrate of the
epicardial border zone (EBZ) of the 5-day infarcted canine heart. Reentry is stabilized …

Spiral waves occur in various types of excitable media and their dynamics determine the
spatial excitation patterns. An important type of spiral wave dynamics is drift, as it can control …

Computational modeling provides a potentially powerful way to integrate structural
properties measured in vitro to physiological functions measured in vivo. Focusing on the …

Sudden cardiac death is often caused by cardiac arrhythmias. Recently, special attention
has been given to a certain arrhythmogenic condition, the long-QT syndrome, which occurs …