Staphylococcus aureus (S. aureus) is a Gram positive bacterium that is carried by about one
third of the general population and is responsible for common and serious diseases. These …

Crohn's disease is a disorder mediated by Tlymphocyteswhich arises in genetically
susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal …

The cytokine interleukin-10 (IL-10) has shown promise in clinical trials for treatment of
inflammatory bowel disease (IBD). Using two mouse models, we show that the therapeutic …

BACKGROUND/AIMS Alterations in synthesis and breakdown of extracellular matrix
components are known to play a crucial role in tissue remodelling during inflammation and …

Treatment options for inflammatory bowel disease (IBD) reflect a continuing shift from
empiricism to strategies based on improved understanding of the pathophysiology of …

Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant
morbidity and mortality in preterm infants. Due to the multifactorial nature of the disease and …

Background: Increased expression of proinflammatory cytokines, including tumour necrosis
factor α, interleukin 6, and interferon γ, as well as activation of proinflammatory signalling …

Crohn's disease and ulcerative colitis are caused by excessive immune reactivity in the gut
wall. Analysis of the type of immune responses ongoing in diseased gut has revealed …

Background Extracellular matrix (ECM) degradation may play a role in villus atrophy in
coeliac disease (CD). Aims To compare the cellular expression of mRNA transcripts for the …

Necrotizing enterocolitis (NEC) is a devastating intra-abdominal emergency in the newborn
period. The disease involves bowel wall inflammation, ischemic necrosis, eventual …