Current knowledge of the aetiology of human tubal ectopic pregnancy
BACKGROUND An ectopic pregnancy is a pregnancy which occurs outside of the uterine
cavity, and over 98% implant in the Fallopian tube. Tubal ectopic pregnancy remains the …
cavity, and over 98% implant in the Fallopian tube. Tubal ectopic pregnancy remains the …
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases
M Vincenzi, A Kremić, A Jouve, R Lattanzi… - Pharmacological …, 2023 - ASPET
The prokineticins (PKs) were discovered approximately 20 years ago as small peptides
inducing gut contractility. Today, they are established as angiogenic, anorectic, and …
inducing gut contractility. Today, they are established as angiogenic, anorectic, and …
The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations
A widely dispersed network of hypothalamic GnRH neurons controls the reproductive axis in
mammals. Genetic investigation of the human disease model of isolated GnRH deficiency …
mammals. Genetic investigation of the human disease model of isolated GnRH deficiency …
[HTML][HTML] Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic …
Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP),
but the underlying mechanisms of these associations are not completely understood …
but the underlying mechanisms of these associations are not completely understood …
Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil
Uterine NK cells (uNK) play a role in the regulation of placentation, but their functions in
nonpregnant endometrium are not understood. We have previously reported suppression of …
nonpregnant endometrium are not understood. We have previously reported suppression of …
EG-VEGF: a key endocrine factor in placental development
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), also named
prokineticin 1, is the canonical member of the prokineticin family. Numerous reports suggest …
prokineticin 1, is the canonical member of the prokineticin family. Numerous reports suggest …
[HTML][HTML] Cotinine exposure increases fallopian tube PROKR1 expression via nicotinic AChRα-7: a potential mechanism explaining the link between smoking and tubal …
Tubal ectopic pregnancy (EP) is the most common cause of maternal mortality in the first
trimester of pregnancy; however, its etiology is uncertain. In EP, embryo retention within the …
trimester of pregnancy; however, its etiology is uncertain. In EP, embryo retention within the …
Prokineticins and their G protein-coupled receptors in health and disease
Prokineticins are two conserved small proteins (~ 8 kDa), prokineticin 1 (PROK1; also called
EG-VEGF) and prokineticin 2 (PROK2; also called Bv8), with an N-terminal AVITGA …
EG-VEGF) and prokineticin 2 (PROK2; also called Bv8), with an N-terminal AVITGA …
Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium
LJ Macdonald, KJ Sales, V Grant… - Molecular Human …, 2011 - academic.oup.com
Abstract Prokineticin 1 (PROK1) signalling via prokineticin receptor 1 (PROKR1) regulates
the expression of several genes with important roles in endometrial receptivity and …
the expression of several genes with important roles in endometrial receptivity and …
[HTML][HTML] Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines
L Ma, Z Li, S Xi, Q Guo, P Zhao, W Li, J Ai… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Objective: Tubal ectopic pregnancy (TEP) remains the most common cause of maternal
morbidity and mortality in the early months of pregnancy. The aim of this study is to perform …
morbidity and mortality in the early months of pregnancy. The aim of this study is to perform …