Heart failure (HF) is an acute or chronic clinical syndrome that results in a decrease in
cardiac output and an increase in intracardiac pressure at rest or upon exertion. The …

For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …

Hypertension is one of the leading risk factors for the development of heart failure. Despite
being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong …

It is now established that sex differences occur in clinical manifestation, disease
progression, and prognosis for both cardiovascular (CVDs) and central nervous system …

This MiniReview describes the essential biochemical and molecular aspects of matrix
metalloproteinases (MMP s) and briefly discusses how they engage in different diseases …

Growing experimental evidence indicates that matrix metalloproteinases (MMPs) are
implicated in many cardiovascular diseases including hypertension and its chronic …

Hypertension is associated with well known structural and functional alterations in both
resistance and conduit arteries, which may be the result from long-lasting high blood …

Heart failure (HF) is one of the major health and economic burdens worldwide, and its
prevalence is continuously increasing. The study of HF requires reliable animal models to …

Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major
contributor to all-cause mortality and disability worldwide. The pathophysiology of …

Hypertension is characterized by maladaptive vascular remodeling and enhanced oxidative
stress in the vascular wall. Peroxynitrite may directly activate latent matrix metalloproteinase …