Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

Breast cancer affects one in seven women worldwide during their lifetime. Widespread
mammographic screening programs and education campaigns allow for early detection of …

Oral squamous cell carcinoma (OSCC) has a high propensity for local failure, which is
attributed to recurrence at the primary site or the development of second primary tumors …

Many of the fundamental molecular mechanisms underlying tumor biology remain elusive
and, thus, developing specific anticancer therapies remains a challenge. The recently …

A discontinuous pattern of LOH at chromosome 3p has been reported in 87% of primary
breast cancers. Despite the identification of several tumor suppressor genes in this region …

Sporadic breast cancer develops through the accumulation of molecular abnormalities in
normal breast tissue, resulting from exposure to estrogens and other carcinogens beginning …

Mutations are abundantly present in tissues of healthy individuals, including the breast
epithelium. Yet it remains unknown whether mutant cells directly induce lesion formation or …

Background Deregulated energetics is a property of most cancer cells. This phenomenon,
known as the Warburg Effect or aerobic glycolysis, is characterized by increased glucose …

Particular N‐glycan structures are known to be associated with breast malignancies by
coordinating various regulatory events within the tumor and corresponding …

Non-coding RNAs (ncRNAs) are untranslated RNA molecules that function to regulate the
expression of numerous genes and associated biochemical pathways and cellular functions …