▪ Abstract During the development of multicellular organisms, cells become different from
one another by changing their genetic program in response to transient stimuli. Long after …

Histone N-termini (tails) undergo diverse post-translational modifications, including
acetylation, phosphorylation, methylation, ubiquitination and ADP-ribosylation (van Holde …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the …

The gametophytic maternal effect mutant medea (mea) shows aberrant growth regulation
during embryogenesis in Arabidopsis thaliana. Embryos derived from mea eggs grow …

COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4
(H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including …

Iterative profile searches and structural modeling show that bacterial DnaG-type primases,
small primase-like proteins from bacteria and archaea, type IA and type II topoisomerases …

The chromo and SET domains are conserved sequence motifs present in chromosomal
proteins that function in epigenetic control of gene expression, presumably by modulating …

The discovery that cancer can be governed above and beyond the level of our DNA
presents a new era for designing therapies that reverse the epigenetic state of a tumour cell …

The spatially, temporally and quantitatively correct expression of a gene requires the
presence not only of intact coding sequence, free of adverse nucleotide changes, but also …

Repression of yeast a cell-specific genes by the global repressor Ssn6/Tup1 has been
linked to a specific organization of chromatin. We report here that Tup1 directly interacts with …