Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

There is much interest in form-fitting, low-modulus, implantable devices or soft robots that
can mimic or assist in complex biological functions such as the contraction of heart muscle …

The developing vertebrate gut tube forms a reproducible looped pattern as it grows into the
body cavity. Here we use developmental experiments to eliminate alternative models and …

Since its coming of age in the mid 1960s, continuum biomechanics has contributed much to
our understanding of human health as well as to disease, injury, and their treatment …

The continuum mechanical treatment of biological growth and remodeling has attracted
considerable attention over the past fifteen years. Many aspects of these problems are now …

The myofiber geometry of the left ventricle (LV) changes gradually from a right-handed helix
in the subendocardium to a left-handed helix in the subepicardium. In this review, we …

Although the need for a functional arterial replacement is clear, the lower blood flow
velocities of small-diameter arteries like the coronary artery have led to the failure of …

Mechanotransduction refers to the conversion of mechanical forces into biochemical or
electrical signals that initiate structural and functional remodeling in cells and tissues. The …

Soft biological tissues often undergo large (nearly) elastic deformations that can be
analyzed using the nonlinear theory of elasticity. Because of the varied approaches to …