The concept of 'successful aging'has long intrigued the scientific community. Despite this
long-standing interest, a consensus definition has proven to be a difficult task, due to the …

In the 15 years since the publication of two previous reviews on restraint stress much
advancement has been made in the field. However, while previous reviews have focused …

We review developments in the study of stress in free-ranging mammals and summarize the
physiological and behavioral components of the stress response. Both the sympathetic …

Alzheimer's disease (AD), the most common cause of dementia among the elderly, may
either represent the far end of a continuum that begins with age-related memory decline or a …

Stress can be defined as a brain–body reaction towards stimuli arising from the environment
or from internal cues that are interpreted as a disruption of homeostasis. The organization of …

The age of an experimental animal can be a critical variable, yet age matters are often
overlooked within neuroscience. Many studies make use of young animals, without …

Alterations in inhibitory interneurons contribute to cognitive deficits associated with several
psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ …

Cognitive functions that require the prefrontal cortex are highly sensitive to aging in humans,
nonhuman primates, and rodents, although the neurobiological correlates of this …

Executive functions supported by prefrontal cortical (PFC) systems provide essential control
and planning mechanisms to guide goal-directed behavior. As such, age-related alterations …

Glucocorticoid signaling plays major roles in energy homeostasis and adaptation to
adversity, and dysregulation of this process is linked to systemic and psychological …