Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Polymers for cytosolic protein delivery

J Lv, Q Fan, H Wang, Y Cheng - Biomaterials, 2019 - Elsevier
Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Catalytic potential of endophytes facilitates synthesis of biometallic zinc oxide nanoparticles for agricultural application

S Saqib, A Nazeer, M Ali, W Zaman, M Younas… - BioMetals, 2022 - Springer
Recent advances fascinated the use of biological resources in combination with metals to
obtain high quality biometals and apply its advantages in different fields. Endophytic …

A vector-free microfluidic platform for intracellular delivery

A Sharei, J Zoldan, A Adamo, WY Sim… - Proceedings of the …, 2013 - National Acad Sciences
Intracellular delivery of macromolecules is a challenge in research and therapeutic
applications. Existing vector-based and physical methods have limitations, including their …

Carbon Helical Nanorobots Capable of Cell Membrane Penetration for Single Cell Targeted SERS Bio‐Sensing and Photothermal Cancer Therapy

Y Chen, R Pan, Y Wang, P Guo, X Liu… - Advanced Functional …, 2022 - Wiley Online Library
Penetration of cell membrane at micro/nano‐scale with untethered probe is of great scientific
significance, yet still challenging. Here, a carbon nanocoil based magnetic nanorobot, which …

High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption

X Ding, MP Stewart, A Sharei, JC Weaver… - Nature biomedical …, 2017 - nature.com
Nuclear transfection of DNA into mammalian cells is challenging yet critical for many
biological and medical studies. Here, by combining cell squeezing and electric-field-driven …

Strategies for interfacing inorganic nanocrystals with biological systems based on polymer-coating

G Palui, F Aldeek, W Wang, H Mattoussi - Chemical Society Reviews, 2015 - pubs.rsc.org
Interfacing inorganic nanoparticles and biological systems with the aim of developing novel
imaging and sensing platforms has generated great interest and much activity. However, the …

Microfluidic and nanofluidic intracellular delivery

J Hur, AJ Chung - Advanced Science, 2021 - Wiley Online Library
Innate cell function can be artificially engineered and reprogrammed by introducing
biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the …

A comprehensive review on intracellular delivery

D Morshedi Rad, M Alsadat Rad… - Advanced …, 2021 - Wiley Online Library
Intracellular delivery is considered an indispensable process for various studies, ranging
from medical applications (cell‐based therapy) to fundamental (genome‐editing) and …

Carbon nanodots@ zeolitic imidazolate framework-8 nanoparticles for simultaneous pH-responsive drug delivery and fluorescence imaging

L He, T Wang, J An, X Li, L Zhang, L Li, G Li, X Wu… - …, 2014 - pubs.rsc.org
A facile two-step method was developed to fabricate green fluorescent carbon nanodots@
zeolitic imidazolate framework-8 nanoparticles (C-dots@ ZIF-8 NPs) with tunable size and …