In Silico Screening and Molecular Dynamics Simulation of Disease‐Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3
Oculocutaneous albinism type III (OCA3), caused by mutations of TYRP1 gene, is an
autosomal recessive disorder characterized by reduced biosynthesis of melanin pigment in …
autosomal recessive disorder characterized by reduced biosynthesis of melanin pigment in …
Computational Analysis of Gly482Ser Single‐Nucleotide Polymorphism in PPARGC1A Gene Associated with CAD, NAFLD, T2DM, Obesity, Hypertension, and …
S Taghvaei, L Saremi, S Babaniamansour - PPAR research, 2021 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐gamma coactivator 1‐alpha (PPARGC1A)
regulates the expression of energy metabolism's genes and mitochondrial biogenesis. The …
regulates the expression of energy metabolism's genes and mitochondrial biogenesis. The …
Computational screening of disease-associated mutations in OCA2 gene
Abstract Oculocutaneous albinism type 2 (OCA2), caused by mutations of OCA2 gene, is an
autosomal recessive disorder characterized by reduced biosynthesis of melanin pigment in …
autosomal recessive disorder characterized by reduced biosynthesis of melanin pigment in …
High‐Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis
KC Das, MU Hossain, M Moniruzzaman… - BioMed Research …, 2022 - Wiley Online Library
HMG‐CoA reductase or HMGCR (3‐hydroxy‐3‐methylglutaryl‐CoA reductase) is a rate‐
limiting enzyme involved in cholesterol biosynthesis. HMGCR plays an important role in the …
limiting enzyme involved in cholesterol biosynthesis. HMGCR plays an important role in the …
The promising novel biomarkers and candidate small molecule drugs in lower‐grade glioma: Evidence from bioinformatics analysis of high‐throughput data
B Zhang, Q Wu, R Xu, X Hu, Y Sun… - Journal of Cellular …, 2019 - Wiley Online Library
Overall survival of patients with low‐grade glioma (LGG) has shown no significant
improvement over the past 30 years, with survival averaging approximately 7 years. This …
improvement over the past 30 years, with survival averaging approximately 7 years. This …
Synthesis, docking and antidiabetic activity of some newer benzamide derivatives as potential glucokinase activators
Background: Glucokinase activators (GKAs) are the new class of candidate drugs which act
on glucokinase (GK) enzyme and show their hypoglycaemic activity. Objective: The present …
on glucokinase (GK) enzyme and show their hypoglycaemic activity. Objective: The present …
In silico comprehensive analysis of coding and non-coding SNPs in human mTOR protein
T Yasmin - Plos one, 2022 - journals.plos.org
The mammalian/mechanistic target of rapamycin (mTOR) protein is an important growth
regulator and has been linked with multiple diseases including cancer and diabetes. Non …
regulator and has been linked with multiple diseases including cancer and diabetes. Non …
In-silico screening of cancer associated mutation on PLK1 protein and its structural consequences
B Kamaraj, V Rajendran, R Sethumadhavan… - Journal of Molecular …, 2013 - Springer
Abstract The Polo-like kinases (Plks) are a conserved subfamily of serine-threonine protein
kinases that have significant roles in cell proliferation. The serine/threonine protein kinases …
kinases that have significant roles in cell proliferation. The serine/threonine protein kinases …
Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1
X Qian, L Qin, G Xing, X Cao - Scientific reports, 2015 - nature.com
Wolfram syndrome (WS) is a rare, progressive, neurodegenerative disorder that has an
autosomal recessive pattern of inheritance. The gene for WS, wolfram syndrome 1 gene …
autosomal recessive pattern of inheritance. The gene for WS, wolfram syndrome 1 gene …
Isolation and structure elucidation of a steroidal moiety from Withania somnifera and in silico evaluation of antimalarial efficacy against artemisinin resistance …
According to the 2021 Malaria report, 241 million clinical episodes with 627000 deaths
penalty was estimated across the worldwide. However, mutation in the propeller domain of …
penalty was estimated across the worldwide. However, mutation in the propeller domain of …