A review of natural polysaccharides: Sources, characteristics, properties, food, and pharmaceutical applications

I Benalaya, G Alves, J Lopes, LR Silva - International Journal of …, 2024 - mdpi.com
Natural polysaccharides, which are described in this study, are some of the most extensively
used biopolymers in food, pharmaceutical, and medical applications, because they are …

Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents

B Bjørndal, L Burri, V Staalesen, J Skorve… - Journal of …, 2011 - Wiley Online Library
Adipose tissue metabolism is closely linked to insulin resistance, and differential fat
distributions are associated with disorders like hypertension, diabetes, and cardiovascular …

[HTML][HTML] Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation

IKN Pettersen, D Tusubira, H Ashrafi, SE Dyrstad… - Mitochondrion, 2019 - Elsevier
Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production.
Regulation occurs through multiple nutrient-and energy-sensitive molecular mechanisms …

The opportunities and challenges of peroxisome proliferator-activated receptors ligands in clinical drug discovery and development

F Hong, P Xu, Y Zhai - International Journal of Molecular Sciences, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are a well-known pharmacological
target for the treatment of multiple diseases, including diabetes mellitus, dyslipidemia …

Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders

N Torres, I Torre-Villalvazo, AR Tovar - The Journal of nutritional …, 2006 - Elsevier
Soybeans have a high-quality protein that has been consumed for approximately 5000
years in Oriental countries. The awareness that soy products are healthy has increased their …

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

JJ Smith, RD Kenney, DJ Gagne, BP Frushour… - BMC systems …, 2009 - Springer
Background Calorie restriction (CR) produces a number of health benefits and ameliorates
diseases of aging such as type 2 diabetes. The components of the pathways downstream of …

The Role of PPARα Activation in Liver and Muscle

L Burri, GH Thoresen, RK Berge - PPAR research, 2010 - Wiley Online Library
PPARα is one of three members of the soluble nuclear receptor family called peroxisome
proliferator‐activated receptor (PPAR). It is a sensor for changes in levels of fatty acids and …

5‐Caffeoylquinic acid decreases diet‐induced obesity in rats by modulating PPARα and LXRα transcription

K Huang, X Liang, Y Zhong, W He… - Journal of the Science of …, 2015 - Wiley Online Library
Abstract Background Chlorogenic acids (CGAs) are widely distributed in plant material,
including foods and beverages. 5‐Caffeoylquinic acid (5‐CQA) is the most studied CGA, but …

Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice

B Bjørndal, EK Alterås, C Lindquist, A Svardal… - Nutrition & …, 2018 - Springer
Background The 4-thia fatty acid tetradecylthiopropionic acid (TTP) is known to inhibit
mitochondrial β-oxidation, and can be used as chemically induced hepatic steatosis-model …

Modulating effects of chlorogenic acid on lipids and glucose metabolism and expression of hepatic peroxisome proliferator-activated receptor-α in golden hamsters …

LI Shu-Yuan, CQ Chang, MA Fu-Ying… - Biomedical and …, 2009 - Elsevier
OBJECTIVE: To examine the effects of chlorogenic acid (CGA) on lipid and glucose
metabolism under a high dietary fat burden and to explore the possible role of peroxisome …