Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the …

Perhaps no disorder of the human brain has aroused more interest among neuroscientists in
recent years than Alzheimer's disease (AD). This common and devastating cerebral …

Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …

Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

Patients with trisomy 21 [Down syndrome (DS)] progressively develop amyloid β-protein
(Aβ) deposits and then other features of Alzheimer's disease (AD), apparently due to …

The pathological findings of Alzheimer* s disease include amyloid deposition in cerebral
blood vessels and in senile plaques. Both deposits are known to include pep-tides that …

Epidemiological and basic science evidence suggest a possible shared pathophysiology
between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). It has even been …

The amyloid beta-protein (A beta) that is progressively deposited in Alzheimer's disease
(AD) arises from proteolysis of the integral membrane protein, beta-amyloid precursor …

The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of
amyloid associated with Alzheimer disease (AD). We have determined the relative …