Enzyme‐mediated cascade reactions are widespread in biosynthesis. To facilitate
comparison with the mechanistic categorizations of cascade reactions by synthetic chemists …

Covering: up to the end of 2017 C–C bond formations are frequently the key steps in
cofactor and natural product biosynthesis. Historically, C–C bond formations were thought to …

Radical S-adenosyl-l-methionine (SAM) enzymes employ a [4Fe–4S] cluster and SAM to
initiate diverse radical reactions via either H-atom abstraction or substrate adenosylation …

Aminomalonate (Ama) is a widespread structural motif in Nature, whereas its biosynthetic
route is only partially understood. In this study, we show that a radical S …

Although photoredox catalysis is complex from a mechanistic point of view, it is also often
surprisingly efficient. In fact, the quantum efficiency of a puzzlingly large portion of …

Radical S-adenosyl-l-methionine (SAM) enzymes catalyze radical mediated chemical
transformations notable for their diversity. The radical mediated reactions that take place in …

OxsB is a B12-dependent radical SAM enzyme that catalyzes the oxidative ring contraction
of 2′-deoxyadenosine 5′-phosphate to the dehydrogenated, oxetane containing …

The recently discovered futalosine-dependent menaquinone biosynthesis pathway employs
radical chemistry for the naphthoquinol core assembly. Mechanistic studies on this pathway …

Cobalamin (Cbl)-dependent radical S-adenosylmethionine (SAM) methyltransferases
catalyze methylation reactions at non-nucleophilic centers in a wide range of substrates …

Arsenosugars are a group of arsenic‐containing ribosides that are found predominantly in
marine algae but also in terrestrial organisms. It has been proposed that arsenosugar …