Salt sensitivity: causes, consequences, and recent advances

MA Bailey, N Dhaun - Hypertension, 2024 - Am Heart Assoc
Salt (sodium chloride) is an essential nutrient required to maintain physiological functions.
However, for most people, daily salt intake far exceeds their physiological need and is …

Targeting inflammation in hypertension

A Deussen, I Kopaliani - Current opinion in nephrology and …, 2023 - journals.lww.com
Although immunomodulation may be advantageous as a causal therapy in hypertension,
targeting immune networks rather than single interleukins appears of major importance …

Systemic delivery of extracellular vesicles attenuates atrial fibrillation in heart failure with preserved ejection fraction

R Zhang, T Mesquita, JH Cho, C Li, L Sanchez… - Clinical …, 2023 - jacc.org
Background Atrial fibrillation (AF) is a common comorbidity in heart failure with preserved
ejection fraction (HFpEF) patients. To date, treatments for HFpEF-related AF have been …

A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF

F Sanhueza-Olivares, MF Troncoso… - Frontiers in …, 2022 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is one of the most complex and most
prevalent cardiometabolic diseases in aging population. Age, obesity, diabetes, and …

Three-vessel coronary infusion of cardiosphere-derived cells for the treatment of heart failure with preserved ejection fraction in a pre-clinical pig model

R Gallet, JB Su, D Corboz, PM Chiaroni, A Bizé… - Basic Research in …, 2023 - Springer
Heart failure with preserved ejection fraction (HFpEF) is a major public health concern. Its
outcome is poor and, as of today, barely any treatments have been able to decrease its …

Oxygen–ozone therapy for myocardial ischemic stroke and cardiovascular disorders

S Pandolfi, S Chirumbolo, M Franzini… - Medical Gas …, 2025 - journals.lww.com
Cardiovascular diseases (CVDs) represent a major concern for human health worldwide.
Emergencies in this field include wide repertories of studies dealing primarily with CVD …

In search of the Holy Grail: Stem Cell Therapy as a Novel Treatment of Heart failure with preserved ejection fraction

O Domaszk, A Skwarek, M Wojciechowska - International Journal of …, 2023 - mdpi.com
Heart failure, a leading cause of hospitalizations and deaths, is a major clinical problem. In
recent years, the increasing incidence of heart failure with preserved ejection fraction …

Renal denervation helps preserve the ejection fraction by preserving endocardial-endothelial function during heart failure

S Pushpakumar, M Singh, Y Zheng… - International Journal of …, 2023 - mdpi.com
Renal denervation (RDN) protects against hypertension, hypertrophy, and heart failure (HF);
however, it is not clear whether RDN preserves ejection fraction (EF) during heart failure …

Combinatorial Effect of Biomaterials and Extracellular Vesicle Therapy for Heart Failure with Reduced Ejection Fraction: A Systematic Review of Preclinical Studies

K Malhotra, S Van Remortel, V Ly… - Advanced Healthcare …, 2023 - Wiley Online Library
Heart failure, a pervasive global health burden, necessitates innovative therapeutic
strategies. Extracellular vesicles (EVs) have emerged as promising contenders for cardiac …

Establishment of a HFpEF model using female Dahl salt-sensitive rats: a valuable tool for elucidating the pathophysiology of HFpEF in women

H Nakashima, K Shinohara, S Matsumoto… - Hypertension …, 2024 - nature.com
The pathogenesis of heart failure with preserved ejection fraction (HFpEF) remains unclear,
and effective treatments are limited. HFpEF is more prevalent in females, indicating potential …