The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm,
and nervous system function have been traced to mutations in genes encoding voltage …

The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1. 5.
This channel predominates inward sodium current (INa) and plays a critical role in …

▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …

1. Prologue 582. The Hodgkin–Huxley formalism for computing the action potential 592.1
The axon action potential model 592.2 Cardiac action potential models 623. Ion-channel …

Atrial standstill (AS) is a rare arrhythmia that occasionally appears to be genetically
determined. This study investigates the genetic background of this arrhythmogenic disorder …