To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

M Giustiniano, A Basso, V Mercalli… - Chemical Society …, 2017 - pubs.rsc.org
The term functionalized isocyanides refers to all those isocyanides in which a neighbouring
functional group can finely tune the reactivity of the isocyano group or can be exploited in …

The Groebke‐Blackburn‐Bienaymé Reaction

A Boltjes, A Dömling - European Journal of Organic Chemistry, 2019 - Wiley Online Library
Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

Diversity-oriented synthesis of fused-imidazole derivatives via Groebke–Blackburn–Bienayme reaction: a review

N Devi, RK Rawal, V Singh - Tetrahedron, 2015 - Elsevier
In recent time, diversity-oriented synthesis of small chemical entities has been emerged as a
possible tool for exploring the intersections between chemistry and biology. These small …

Iodine catalyzed synthesis of imidazo [1, 2-a] pyrazine and imidazo [1, 2-a] pyridine derivatives and their anticancer activity

R Krishnamoorthy, P Anaikutti - RSC advances, 2023 - pubs.rsc.org
An efficient iodine-catalyzed method for synthesizing imidazo [1, 2-a] pyrazines and imidazo
[1, 2-a] pyridines via one-pot three-component condensations has been reported. The …

Recent advances in development of imidazo [1, 2-a] pyrazines: synthesis, reactivity and their biological applications

R Goel, V Luxami, K Paul - Organic & biomolecular chemistry, 2015 - pubs.rsc.org
Imidazo [1, 2-a] pyrazine acts as a versatile scaffold in organic synthesis and drug
development. This review article is an effort to compile the progress made in synthetic …

Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible …

SK Guchhait, C Madaan - Organic & Biomolecular Chemistry, 2010 - pubs.rsc.org
With the development of a novel microwave-assisted one-pot tandem de-tert-butylation of
tert-butyl amine in an Ugi-type multicomponent reaction product, tert-butyl isocyanide as a …

Catalyst-free synthesis of imidazo [1, 2-a] pyridines via Groebke multicomponent reaction

N Azizi, S Dezfooli - Environmental Chemistry Letters, 2016 - Springer
Deep eutectic solvents are becoming more popular nowadays since they are green, safe
and often save raw materials and energy compared to organic solvent. Due to the …

Synthetic approaches and functionalizations of imidazo [1, 2-a] pyrimidines: an overview of the decade

R Goel, V Luxami, K Paul - RSC advances, 2015 - pubs.rsc.org
Imidazo [1, 2-a] pyrimidine has been receiving significant attention in the synthetic chemistry
community through different chemosynthetic methodologies viz., multicomponent reactions …

Imidazo[1,2-a]quinoxalines Accessed via Two Sequential Isocyanide-Based Multicomponent Reactions

M Krasavin, S Shkavrov, V Parchinsky… - The Journal of …, 2009 - ACS Publications
Imidazo[1,2-a]quinoxalines Accessed via Two Sequential Isocyanide-Based
Multicomponent Reactions | The Journal of Organic Chemistry ACS ACS Publications …

Synthesis of Spiro[chromene-imidazo[1,2-a]pyridin]-3′-imines via 6-exo-dig Cyclization Reaction

B Nayebzadeh, K Amiri, H Khosravi… - The Journal of …, 2021 - ACS Publications
A transition-metal-free postmodification of the Groebke–Blackburn–Bienaymé (GBB)
reaction for the synthesis of spiro [chromene-imidazo [1, 2-a] pyridin]-3′-imine was …