Pulmonary interstitial matrix and lung fluid balance from normal to the acutely injured lung

E Beretta, F Romanò, G Sancini, JB Grotberg… - Frontiers in …, 2021 - frontiersin.org
This review analyses the mechanisms by which lung fluid balance is strictly controlled in the
air-blood barrier (ABB). Relatively large trans-endothelial and trans-epithelial Starling …

Polymer-and hybrid-based biomaterials for interstitial, connective, vascular, nerve, visceral and musculoskeletal tissue engineering

A Abalymov, B Parakhonskiy, AG Skirtach - Polymers, 2020 - mdpi.com
In this review, materials based on polymers and hybrids possessing both organic and
inorganic contents for repairing or facilitating cell growth in tissue engineering are …

Permeability of epithelial/endothelial barriers in transwells and microfluidic bilayer devices

TS Frost, L Jiang, RM Lynch, Y Zohar - Micromachines, 2019 - mdpi.com
Lung-on-a-chip (LoC) models hold the potential to rapidly change the landscape for
pulmonary drug screening and therapy, giving patients more advanced and less invasive …

Real‐Time Measurement of Cell Mechanics as a Clinically Relevant Readout of an In Vitro Lung Fibrosis Model Established on a Bioinspired Basement Membrane

A Doryab, MB Taskin, P Stahlhut, J Groll… - Advanced …, 2022 - Wiley Online Library
Lung fibrosis, one of the major post‐COVID complications, is a progressive and ultimately
fatal disease without a cure. Here, an organ‐and disease‐specific in vitro mini‐lung fibrosis …

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

CM Bobba, Q Fei, V Shukla, H Lee, P Patel… - Nature …, 2021 - nature.com
Mechanical ventilation generates injurious forces that exacerbate lung injury. These forces
disrupt lung barrier integrity, trigger proinflammatory mediator release, and differentially …

A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions

A Doryab, MB Taskin, P Stahlhut… - … in Bioengineering and …, 2021 - frontiersin.org
Evolution has endowed the lung with exceptional design providing a large surface area for
gas exchange area (ca. 100 m2) in a relatively small tissue volume (ca. 6 L). This is possible …

Heart-on-a-chip using human iPSC-derived cardiomyocytes with an integrated vascular endothelial layer based on a culture patch as a potential platform for drug …

Y Tang, F Tian, X Miao, D Wu, Y Wang, H Wang… - …, 2022 - iopscience.iop.org
Many strategies have been adopted to construct in vitro myocardium models, which are of
great value to both drug cardiotoxicity evaluation and cardiovascular drug development. In …

A biomimetic, copolymeric membrane for cell‐stretch experiments with pulmonary epithelial cells at the air‐liquid interface

A Doryab, MB Taskin, P Stahlhut… - Advanced functional …, 2021 - Wiley Online Library
Chronic respiratory diseases are among the leading causes of death worldwide, but only
symptomatic therapies are available for terminal illness. This in part reflects a lack of …

BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A–YAP axis

G Mao, C Gong, Z Wang, M Sun, Z Pei… - Acta Pharmacologica …, 2021 - nature.com
Sulfur mustard (SM) is a highly toxic chemical warfare agent that causes acute lung injury
(ALI) and/or acute respiratory distress syndrome (ARDS). There are no effective therapeutic …

A robust protocol for decellularized human lung bioink generation amenable to 2D and 3D lung cell culture

M Dabaghi, N Saraei, MB Carpio, V Nanduri… - Cells, 2021 - mdpi.com
Decellularization efforts must balance the preservation of the extracellular matrix (ECM)
components while eliminating the nucleic acid and cellular components. Following effective …