Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate
janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are
small (104 amino acids) and have a striking relationship to the acute phase response with …

Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue
injuries, contributes to host defense through the stimulation of acute phase responses …

Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When
homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and …

Bone is a tissue undergoing continuous building and degradation. This remodelling is a
tightly regulated process that can be disturbed by many factors, particularly hormonal …

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

In the late 1960s, the essential role of T cells in antibody production was reported. This led to
our hypothesis that T-cell-derived soluble factors would have to be involved in the activation …

Adult mammals respond to tissue damage by implementing the acute phase response,
which comprises a series of specific physiological reactions. This review outlines the …

The family of cytokines signalling through the common receptor subunit gp130 comprises
interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor …