A review of how the saffron (Crocus sativus) petal and its main constituents interact with the Nrf2 and NF-κB signaling pathways
M Ghasemzadeh Rahbardar… - … Archives of Pharmacology, 2023 - Springer
The primary by-product of saffron (Crocus sativus) processing is saffron petals, which are
produced in large quantities but are discarded. The saffron petals contain a variety of …
produced in large quantities but are discarded. The saffron petals contain a variety of …
Environmental toxicants and nephrotoxicity: implications on mechanisms and therapeutic strategies
Kidneys are one of the most important organs in the human body. In addition to filtering 200
liters of fluid every 24 hours, the kidney also regulates acid-base balance, maintains …
liters of fluid every 24 hours, the kidney also regulates acid-base balance, maintains …
Mechanism of evodiamine blocking Nrf2/MAPK pathway to inhibit apoptosis of grass carp hepatocytes induced by DEHP
Y Lei, W Zhang, M Gao, H Lin - … and Physiology Part C: Toxicology & …, 2023 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is often used as a plasticizer for plastic products,
and its excessive use can cause irreversible damage to aquatic animals and humans …
and its excessive use can cause irreversible damage to aquatic animals and humans …
Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 …
X Wang, M Gao, X Lu, Y Lei, J Sun, M Ren, T Xu… - Journal of …, 2024 - Elsevier
Abstract Mono-2-ethylhexyl phthalate (MEHP) is the major biologically active metabolite of
Di (2-ethylhexyl) phthalate (DEHP). This MEHP mono-ester metabolite can be transported …
Di (2-ethylhexyl) phthalate (DEHP). This MEHP mono-ester metabolite can be transported …
Exploring the nephrotoxicity and molecular mechanisms of Di-2-ethylhexyl phthalate: A comprehensive review
Y Liu, X Zhang, R Yi, Q Tian, J Xu, X Yan, J Ma… - Chemico-Biological …, 2024 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP), a widely applied plasticizer in various products,
can be absorbed into the human body through several channels and accumulate in the …
can be absorbed into the human body through several channels and accumulate in the …
Dimethyl fumarate attenuates di-(2-ethylhexyl) phthalate-induced nephrotoxicity through the Nrf2/HO-1 and NF-κB signaling pathways
This study aimed to clarify the nephroprotective effect of dimethyl fumarate (DMF) against Di
(2-ethylhexyl) phthalate (DEHP)-induced nephrotoxicity in both in vitro and in vivo models …
(2-ethylhexyl) phthalate (DEHP)-induced nephrotoxicity in both in vitro and in vivo models …
[HTML][HTML] Quercetin, the ingredient of xihuang pills, inhibits hepatocellular carcinoma by regulating autophagy and macrophage polarization
R Wu, T Zhou, J Xiong, Z Zhang, S Tian… - Frontiers in Bioscience …, 2022 - imrpress.com
Background: The key active component (s) in an anti-tumor preparation used in traditional
Chinese medicine, Xihuang Pills, remains unclear. Methods: We used a network …
Chinese medicine, Xihuang Pills, remains unclear. Methods: We used a network …
Role of melatonin and quercetin as countermeasures to the mitochondrial dysfunction induced by titanium dioxide nanoparticles
Aim Due to the growing commercialization of titanium dioxide nanoparticles (TNPs), it is
necessary to use these particles in a manner that is safe, healthy and environmental friendly …
necessary to use these particles in a manner that is safe, healthy and environmental friendly …
Di (2-ethylhexyl) phthalate mediates oxidative stress and activates p38MAPK/NF-kB to exacerbate diabetes-induced kidney injury in vitro and in vivo models
WJ Ding, SL Huang, S Huang, WP Xu… - Toxicology …, 2023 - academic.oup.com
Abstract Plasticizer di (2-ethylhexyl) phthalate (DEHP) is employed to make polyethylene
polymers. Some studies in epidemiology and toxicology have shown that DEHP exposure …
polymers. Some studies in epidemiology and toxicology have shown that DEHP exposure …
Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory
MM Elseweidy, NG Harb, AA Ali, RMA El-Aziz… - Naunyn-Schmiedeberg's …, 2024 - Springer
Abstract Di-2-ethylhexyl phthalate (DEHP) is a common plasticizer with a deleterious impact
on testicular functionality and male fertility. Growing evidence implicates ferroptosis as one …
on testicular functionality and male fertility. Growing evidence implicates ferroptosis as one …