Due to its safety, convenience, low cost and good compliance, oral administration attracts
lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory …

In pharmaceutical research and development, various new chemical entities (NCE) are
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …

Background Carvedilol, the anti-hypertensive drug, has poor bioavailability when
administered orally. Ethosomes-mediated transdermal delivery is considered a potential …

Dendritic nanovectors-based drug delivery has gained significant attention in the past
couple of decades. Dendrimers play a crucial role in deciding the solubility of sparingly …

In this work, a novel strategy that combined molecular thermodynamic and machine learning
was proposed to accurately predict the solubility of drugs in various solvents. The strategy …

Introduction: Interest in hot-melt extrusion (HME) technology for novel applications is
growing day by day, which is evident from several hundred publications within the last 5 …

In this study, a solidified self-nanoemulsifying drug delivery system (solidified SNEDDS) and
surface-modified microspheres were developed for enhancing the oral bioavailability of …

2D nanomaterial phosphorene is a chemistically stable, biocompatible, and biodegradable
drug delivery platform. This study investigates the drug loading efficiency of phosphorene for …

Continuous antisolvent crystallization of Dolutegravir Sodium was studied using a novel
device integrating the microfluidic continuous crystallizer and the agitated crystallizer. This …

This study aimed to investigate whether hot-melt extrusion (HME) processing can modify the
interactions between drugs, cyclodextrins and polymers, and in turn alter the microstructure …