Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Adjuvant physiochemistry and advanced nanotechnology for vaccine development
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …
Selective STING stimulation in dendritic cells primes antitumor T cell responses
B Jneid, A Bochnakian, C Hoffmann, F Delisle… - Science …, 2023 - science.org
T cells that recognize tumor antigens are crucial for mounting antitumor immune responses.
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …
A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs
Z Liu, J Zhou, W Xu, W Deng, Y Wang, M Wang… - Cell research, 2022 - nature.com
The emergence of SARS-CoV-2 variants and potentially other highly pathogenic
sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines. Here, we …
sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines. Here, we …
Platforms, advances, and technical challenges in virus-like particles-based vaccines
R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …
Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines
J Zhou, Z Liu, G Zhang, W Xu, L Xing… - Journal of Medical …, 2023 - Wiley Online Library
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
variants with high transmission rates and striking immune evasion have posed a serious …
variants with high transmission rates and striking immune evasion have posed a serious …
cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice
Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently
prevent infectious diseases and are safe in animal models and humans. In this study, we …
prevent infectious diseases and are safe in animal models and humans. In this study, we …
[HTML][HTML] cGAS/cGAMP/STING signal propagation in the tumor microenvironment: key role for myeloid cells in antitumor immunity
VE Mekers, VM Kho, M Ansems, GJ Adema - Radiotherapy and Oncology, 2022 - Elsevier
Abstract Cyclic GMP-AMP synthase (cGAS), second messenger 2′ 3′-cyclic GMP-AMP
(cGAMP) and stimulator of interferon genes (STING) are fundamental for sensing …
(cGAMP) and stimulator of interferon genes (STING) are fundamental for sensing …
Virus-like particles against infectious disease and cancer: guidance for the nano-architect
Highlights•Studying VLPs gives important insights into how the immune system makes
decisions.•Spacing antigens using DNA indicates the optimal separation for B cell …
decisions.•Spacing antigens using DNA indicates the optimal separation for B cell …
Progress of cGAS-STING signaling in response to SARS-CoV-2 infection
Y Wu, M Zhang, C Yuan, Z Ma, W Li, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is an epidemic respiratory disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can cause infections in …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can cause infections in …