Recent advances in subcellular imaging transcriptomics platforms have enabled high-
resolution spatial mapping of gene expression, while also introducing significant analytical …

Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake,
and therefore have instructive roles in synaptic function and neuronal response properties …

The islets of Langerhans, responsible for regulating blood glucose in vertebrates, are
clusters of endocrine cells distributed throughout the exocrine pancreas. The spatial …

The language network of the human brain has core components in the inferior frontal cortex
and superior/middle temporal cortex, with left-hemisphere dominance in most people …

During the early stages of Alzheimer's disease (AD) in both mouse models and human
patients, soluble forms of Amyloid-β 1–42 oligomers (Aβ42o) trigger loss of excitatory …

Experience-and activity-dependent transcription is a candidate mechanism to mediate
development and refinement of specific cortical circuits. Here, we demonstrate that the …

Investigators conducting behavioral experiments often need precise control over the timing
of the delivery of stimuli to subjects and to collect the precise times of the subsequent …

Chemical synapses are essential for neuronal information storage and relay. The synaptic
signal received or sent from spatially distinct subcellular compartments often generates …

Typical differential single-nucleus gene expression (snRNA-seq) analyses in Alzheimer's
disease (AD) provide fixed snapshots of cellular alterations, making the accurate detection …

The axon guidance proteins, Roundabout (Robo) receptors play a critical role in
morphogenesis of the islets of Langerhans. Mice with a β cell‐selective deletion of Robo …