Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

Netrins are secreted proteins that regulate axon guidance and neuronal migration. Deleted
in colorectal cancer (DCC) is a well-established netrin-1 receptor mediating attractive …

Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …

Netrin-1 is a guidance cue that can trigger either attraction or repulsion effects on migrating
axons of neurons, depending on the repertoire of receptors available on the growth cone …

Netrin-1 is a member of the laminin-like protein family and was initially identified as a potent
chemotactic molecule involved in axonal guidance and cell migration during embryonic …

The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-
1, and this is important for neuronal and vascular development and for limitation of cancer …

Dependence receptors are known to promote survival and positive signaling such as
proliferation, migration, and differentiation when activated, but to actively trigger apoptosis …

Despite the identification of Aβ plaques and NFTs as biomarkers for Alzheimer's disease
(AD) pathology, therapeutic interventions remain elusive, with neither an absolute …

Recent studies have shown that peripheral nerves play an important role in the progression
of breast cancer. Breast cancer cells (BCCs) promote local peripheral nerve growth and …