Synthetic approaches to 1, 4-dicarbonyl compounds
Abstract The synthesis of 1, 4-dicarbonyls is a considerable challenge to organic chemists.
While classical strategies to form 1, n-dioxygenated fragments, in which n is an odd number …
While classical strategies to form 1, n-dioxygenated fragments, in which n is an odd number …
Regiodivergent Organocatalytic Reactions
Organocatalysts are abundantly used for various transformations, particularly to obtain
highly enantio-and diastereomeric pure products by controlling the stereochemistry. These …
highly enantio-and diastereomeric pure products by controlling the stereochemistry. These …
N-Heterocyclic carbene (NHC)-catalyzed oxidation of unactivated aldimines to amides via imine umpolung under aerobic conditions
Herein, we disclose an NHC-catalyzed aerobic oxidation of unactivated aldimines for the
synthesis of amides via umpolung of imines proceeding through an aza-Breslow …
synthesis of amides via umpolung of imines proceeding through an aza-Breslow …
NHC-Catalyzed Formal [4 + 2] Annulation of o-Formyl-Tethered Michael Acceptors and Ynones to Access Highly Functionalized Naphthalene Derivatives
Herein we demonstrate a novel organocatalytic method to access multifunctionalized
naphthalenes via an NHC-catalyzed reaction of ynones and o-formyl-tethered Michael …
naphthalenes via an NHC-catalyzed reaction of ynones and o-formyl-tethered Michael …
NHC-Catalyzed Umpolung Driven Intramolecular Cyclizations for the Generation of 3, 4-Cycloheptanone Annulated Tetracyclic Indole Derivatives
PC Behera, B Anilkumar, JB Nanubolu… - Organic Letters, 2024 - ACS Publications
In this Letter, we disclose the development and exploitation of umpolung reactivity of N-
heterocyclic carbene (NHC) organocatalysts in generating tetracyclic indole derivatives with …
heterocyclic carbene (NHC) organocatalysts in generating tetracyclic indole derivatives with …
Carbene-Catalyzed Tandem Imine Umpolung–Intramolecular Aza-Conjugate Addition–Oxidation to Access N-Substituted Isoindolinones
Herein, we have described a novel N-heterocyclic carbene (NHC)-catalyzed synthesis of N-
substituted isoindolinone acetates. The presented transformation proceeds through NHC …
substituted isoindolinone acetates. The presented transformation proceeds through NHC …
Sequential One-Pot Carbene-Catalyzed Intramolecular Stetter Reaction and Acid-Mediated Condensation: Access to Heteroatom Analogues of π-Extended …
In this Letter, we disclose a simple and effective method to access a variety of phenanthro [9,
10-b] furan and 1 H-dibenzo [e, g] indole derivatives based on the design of a carbene …
10-b] furan and 1 H-dibenzo [e, g] indole derivatives based on the design of a carbene …
Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells
D Pamarthy, SK Behera, S Swain… - Drug Development …, 2023 - Wiley Online Library
Papillary thyroid carcinoma contributes to about 80% of the total thyroid cancer cases.
BRAFV600E is a frequently occurring mutation in PTCs. Although several BRAF inhibitors …
BRAFV600E is a frequently occurring mutation in PTCs. Although several BRAF inhibitors …
Photocatalyzed Energy Transfer for Atom Economical Synthesis of O‐Bridged Tricyclo‐Fused Cyclopropane Derivatives
Herein, we have disclosed a feasible approach to access oxygen bridged tricycle‐fused
cyclopropane derivatives via visible light mediated photocatalyzed energy transfer process …
cyclopropane derivatives via visible light mediated photocatalyzed energy transfer process …
Total Syntheses of h5‐HT2A Receptor Antagonist, FPTase Inhibitor, FGIN‐1‐27 and its Analog by Exploiting NHC‐Catalyzed Imine Umpolung as Key Step
The total syntheses of h5‐HT2A receptor antagonist, FPTase inhibitor, FGIN‐1‐27 and its
analog have been accomplished from readily accessible starting materials such as ortho …
analog have been accomplished from readily accessible starting materials such as ortho …