Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

[HTML][HTML] New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities

M Ashrafizadeh, S Mirzaei, F Hashemi, A Zarrabi… - Biomedicine & …, 2021 - Elsevier
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …

Association of the epithelial–mesenchymal transition (EMT) with cisplatin resistance

M Ashrafizadeh, A Zarrabi, K Hushmandi… - International journal of …, 2020 - mdpi.com
Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

[HTML][HTML] A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects

YX Zhou, XH Gong, H Zhang, C Peng - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Increasing pharmacological evidence supports that paeoniflorin, a water-soluble
monoterpene glycoside isolated from Paeonia lactiflora Pall.(Shaoyao in Chinese), has a …

Cytoskeletal dynamics in epithelial-mesenchymal transition: insights into therapeutic targets for cancer metastasis

A Datta, S Deng, V Gopal, KCH Yap, CE Halim, ML Lye… - Cancers, 2021 - mdpi.com
Simple Summary The epithelial to mesenchymal transition (EMT) is a well-documented
process in the study of cancer metastases. The cytoskeleton is an intricate network involved …

Wnt signaling in triple-negative breast cancer

SÖG Pohl, N Brook, M Agostino, F Arfuso, AP Kumar… - Oncogenesis, 2017 - nature.com
Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

D Parama, M Boruah, K Yachna, V Rana, K Banik… - Life sciences, 2020 - Elsevier
Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression

YR Puar, MK Shanmugam, L Fan, F Arfuso, G Sethi… - Biomedicines, 2018 - mdpi.com
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement

V Aggarwal, HS Tuli, M Tania, S Srivastava… - Seminars in cancer …, 2022 - Elsevier
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of
epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid …