Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
which is characterized by the absence of estrogen receptor (ER) and progesterone receptor …

Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who
respond to poly (ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical …

Triple-negative breast cancer (TNBC) is a subtype of aggressive breast cancer and
characterized by a lack of the expression of estrogen receptor, progesterone receptor and …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer
susceptibility, and the proteins encoded by these genes have distinct functions in related …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Background: Inherited mutations in the BRCA1 gene may be responsible for almost half of
inherited breast carcinomas. However, somatic (acquired) mutations in BRCA1 have not …

Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancers. It is a
heterogeneous disease, not only on the molecular level, but also on the pathologic and …

The discovery of the first gene associated with hereditary breast cancer, BRCA1, was
anticipated to greatly increase our understanding of both hereditary and sporadic forms of …