[HTML][HTML] Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L.(pomegranate) plant extracts: A review

N Maphetu, JO Unuofin, NP Masuku, C Olisah… - Biomedicine & …, 2022 - Elsevier
Punica granatum L (pomegranate) is one of the Mediterranean medicinal plants that has
been used for generations in treating ulcers, diarrhea, and male infertility. Increasing …

Main drivers of (poly) phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

CE Iglesias-Aguirre, A Cortés-Martín… - Food & function, 2021 - pubs.rsc.org
Despite the high human interindividual variability in response to (poly) phenol consumption,
the cause-and-effect relationship between some dietary (poly) phenols (flavanols and olive …

[HTML][HTML] Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota

R García-Villalba, FA Tomás-Barberán… - Molecular Aspects of …, 2023 - Elsevier
Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but
extensively metabolized by the human gut microbiota to produce different urolithins (Uros) …

[HTML][HTML] Evidence for health properties of pomegranate juices and extracts beyond nutrition: A critical systematic review of human studies

JA Giménez-Bastida, MÁ Ávila-Gálvez, JC Espín… - Trends in Food Science …, 2021 - Elsevier
Background The consumption of pomegranate juices and extracts has long been linked to
many health benefits beyond nutrition, described mainly by innumerable preclinical studies …

Urolithins: a comprehensive update on their metabolism, bioactivity, and associated gut microbiota

R García‐Villalba, JA Giménez‐Bastida… - Molecular nutrition & …, 2022 - Wiley Online Library
Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins
and ellagic acid, are discovered by the research group in humans almost 20 years ago …

Antioxidant phytochemicals as potential therapy for diabetic complications

OOP Akpoveso, EE Ubah, G Obasanmi - Antioxidants, 2023 - mdpi.com
The global prevalence of diabetes continues to increase partly due to rapid urbanization and
an increase in the aging population. Consequently, this is associated with a parallel …

Anthocyanins-gut microbiota-health axis: A review

A Liang, W Leonard, JT Beasley, Z Fang… - Critical Reviews in …, 2023 - Taylor & Francis
Anthocyanins are a subclass of flavonoids responsible for color in some fruits and
vegetables with potent antioxidative capacity. During digestion, a larger proportion of dietary …

Health benefits of dietary polyphenols: Insight into interindividual variability in absorption and metabolism

B Zhang, Y Zhang, X Xing, S Wang - Current Opinion in Food Science, 2022 - Elsevier
Highlights•Latest studies on interindividual variability in health effects of polyphenols.•The
role of gene polymorphisms is worth further study.•Identification of microbial metabolic …

New insights into the metabolism of the flavanones eriocitrin and hesperidin: A comparative human pharmacokinetic study

MÁ Ávila-Gálvez, JA Giménez-Bastida… - Antioxidants, 2021 - mdpi.com
The intake of hesperidin-rich sources, mostly found in orange juice, can decrease
cardiometabolic risk, potentially linked to the gut microbial phase-II hesperetin derivatives …

Urolithins: potential biomarkers of gut dysbiosis and disease stage in Parkinson's patients

M Romo-Vaquero, E Fernández-Villalba… - Food & Function, 2022 - pubs.rsc.org
Gut microbiota alteration (gut dysbiosis) occurs during the onset and progression of
Parkinson's disease. Gut dysbiosis biomarkers could be relevant to prodromal disease …