Covalent modification of proteins with ubiquitin is essential for the majority of biological
processes in mammalian cells. Numerous proteins are conjugated with single or multiple …

Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …

Biological effects of high-LET (linear energy transfer) radiation have received increasing
attention, particularly in the context of more efficient radiotherapy and space exploration …

Ionizing radiation (IR)-induced damage confers functional and conformational changes to
nuclear chromatin associated with DNA single and double strand breaks. This leads to the …

Complex functioning of the genome in the cell nucleus is controlled at different levels:(a) the
DNA base sequence containing all relevant inherited information;(b) epigenetic pathways …

From the very beginnings of radiotherapy, a crucial question persists with how to target the
radiation effectiveness into the tumor while preserving surrounding tissues as undamaged …

DNA double stranded breaks (DSBs) are the most serious type of lesions introduced into
chromatin by ionizing radiation. During DSB repair, cells recruit different proteins to the …

Rationale: Patients with chronic kidney disease (CKD) have an exceedingly high
cardiovascular risk; which further increases in patients on peritoneal dialysis (PD). The …

Simple Summary Radiation-induced double-strand breaks (DSBs) are the most toxic and
most difficult to repair DNA lesions and are very heterogeneous. These characteristics place …

DNA double strand breaks (DSB) are the most severe damages in chromatin induced by
ionizing radiation. In response to such environmentally determined stress situations, cells …