Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …

The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Accumulating evidences indicated that hyperuricemia was an independent risk factor for
kidney diseases and contributed to kidney fibrosis. Preventing and treating renal fibrosis …

Fibrosis is a pathological process characterized by accumulation of fibrous connective tissue
in organs, leading to organ malfunction and failure. At the cellular level, tissue injury or …

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are lethal pulmonary
diseases. Cigarette consumption is the main cause for development of COPD, while CF is …

Glaucoma, a progressive and irreversible optic neuropathy, is one of the leading causes of
vision impairment worldwide. Elevation of intraocular pressure (IOP) due to transforming …

Overexpression of EGFR is often associated with advanced stage disease and poor
prognosis. In certain cancers, Src works synergistically with EGFR to promote proliferation …

Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR mutations. It is
characterized by high NaCl concentration in sweat and the production of a thick and sticky …

CFTR is a cAMP‐regulated chloride channel, whose mutations produce cystic fibrosis. The
impairment of CFTR activity increases the intracellular Cl− concentration, which in turn …