Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

A number of reactive oxygen and nitrogen species are produced during normal metabolism
in human body. These species can be both radical and non-radical and have varying …

Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme
activities are increasingly implicated in the induction and progression of neurodegenerative …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Ferroptosis is a recently defined form of cell death with the involvement of iron and reactive
oxygen species (ROS), which is distinct from apoptosis, autophagy and other forms of cell …

Glutathione (GSH) was discovered in yeast cells in 1888. Studies of GSH in mammalian
cells before the 1980s focused exclusively on its function for the detoxication of xenobiotics …