In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …

Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …

In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …

To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in
vivo, we compared the gene expression profiles of highly purified HSCs and non-self …

Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell
microenvironment provides factors and elements that play significant roles in controlling the …

Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into
bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs …

Adult stem cells hold many promises for future clinical applications and regenerative
medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so …

The intricate patterning processes that establish the complex vascular system during
development depend on a combination of intrinsic pre-patterning and extrinsic responses to …

The stem cell niche is composed of a specialized population of cells that plays an essential
role in regulating adult stem cell self-renewal and differentiation. In adults, osteoblasts …