Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic
differences among a variety of cell populations. It paves the way to studying biological …

High-throughput screening (HTS) has been postulated in several quarters to be a
contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it …

PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin–proteasome system to
degrade a protein of interest for therapeutic benefit. Advances made in targeted protein …

Motivation: High-throughput phenotypic assays reveal information about the molecules that
modulate biological processes, such as a disease phenotype and a signaling pathway. In …

Repurposing and repositioning drugs—discovering new uses for existing and experimental
medicines—is an attractive strategy for rescuing stalled pharmaceutical projects, finding …

High-throughput screening (HTS) can efficiently assay multiple discrete biological reactions
using multi-well microplates. The choice of microplate is a crucial yet often overlooked …

Automated microscopes are now widespread in biological research. They enable the
unprecedented collection of images at a rate which outpaces researchers' ability to visually …

More therapeutic monoclonal antibodies and antibody-based modalities are in development
today than ever before, and a faster and more accurate drug discovery process will ensure …

IgA nephropathy (IgAN), the most common GN worldwide, is characterized by circulating
galactose-deficient IgA (gd-IgA) that forms immune complexes. The immune complexes are …

Background: Drug discovery is the process of discovering and designing drugs, which
includes target identification, target validation, lead identification, lead optimization and …