Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …

De novo biosynthesis of fatty acids is an iterative process requiring strict regulation of the
lengths of the produced fatty acids. In this review, we focus on the factors determining chain …

Orlistat, or tetrahydrolipstatin (THL), is an FDA-approved antiobesity drug with potential
antitumor activities. Cellular off-targets and potential side effects of Orlistat in cancer …

Lipids constitute some of nature's most abundant molecules, being found in virtually all
forms of life. They are derived by condensation reactions involving acetate units and may be …

Introduction: Elevated lipogenesis has been associated with a variety of diseases including
obesity, cancer and nonalcoholic fatty liver disease (NAFLD). Fatty acid synthase (FASN) …

Human fatty acid synthase (FASN) is a 270-kDa cytosolic dimeric enzyme that is responsible
for palmitate synthesis. FASN is slowly emerging and rediscovered as a marker for …

Fatty acid synthase (FAS) is uniquely expressed at high levels in cancer cells and adipose
tissue. The objectives of this study were to identify, purify and validate soy FAS inhibitory …

De novo fatty acid biosynthesis in humans is accomplished by a multidomain protein, the
Type I fatty acid synthase (FAS). Although ubiquitously expressed in all tissues, fatty acid …

Tetrahydrolipstatin (THL) is bactericidal but its precise target spectrum is poorly
characterized. Here, we used a THL analog and activity-based protein profiling to identify …